Microbiome Modulation Uncouples Efficacy and Toxicity Induced by Programmed Death-1/Programmed Death-Ligand1 Blockade
Laura Lucia Cogrossi, Anna Policastro, Paola Zordan, Matteo Grioni, Anna Tosi, Nathalie RIZZO, Benedetta Mattorre, Marco Lorenzoni, Greta Meregalli, Sofia Sisti, Francesca Sanvito, Alessandro Palmioli, Cristina Airoldi, Aurora Maurizio, Marta Chesi, , Matteo Bellone
This study shows that administering Prevotella melaninogenica to mice with multiple myeloma delays disease progression and enhances the efficacy of PD-1/PD-L1 blockade while reducing toxicity.
Nature Communications · Nov 24, 2025Peer-reviewedImmunology