Pilib Ó Broin

Altered Frontoparietal, Temporal and Sensorimotor Structure-Function Coupling and Its Genetic Underpinnings in Bipolar Disorder

This study identifies altered structure-function coupling in bipolar disorder and links these changes to genetic loci involved in neuronal development and signaling.

Neonatal social communication and single genes predict the variability of post-pubertal social behavior in a mouse model of paternal 15q11-13 duplication

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

Deriving Mendelian Randomization-based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder

This study uses Mendelian Randomization to identify causal relationships between neuroimaging phenotypes and bipolar disorder, finding that white matter tract variations have larger causal effects on BD.

Comparing the XGBoost machine learning algorithm to polygenic scoring for the prediction of intelligence based on genotype data

This study compares XGBoost machine learning to polygenic scoring for predicting intelligence from genotype data, finding similar performance with fewer SNPs.

Thirteen independent genetic loci associated with preserved processing speed in a study of cognitive resilience in 330,097 individuals in the UK Biobank

The paper identifies 13 genetic loci associated with cognitive resilience using GWAS-by-subtraction in UK Biobank data, showing enrichment in brain regions and cell types.

Transcriptional regulation of neonatal neural stem cells is a determinant of social behavior

The paper investigates how Tbx1 deficiency in neonatal neural stem cells affects social behavior and identifies its role in neurodevelopmental disorders.

Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons

The paper identifies genes regulated by MEF2C during neurodevelopment that are associated with schizophrenia, intelligence, and neurodevelopmental disorders, with different genetic variants affecting distinct cell types and phenotypes.