Author

Jannes Straub

German Cancer Research CenterORCID 0000-0002-7178-1663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:ATAC-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Ana Martín-VillalbaiD· 1 shared Annika MartiniD· 1 shared Atehsa SahaguniD· 1 shared Aylin Korkmaz· 1 shared Bettina WeigeliD· 1 shared Bryce LimiD· 1 shared Cedar SchlooiD· 1 shared Cornelis BlauwendraatiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperNeuroscience

Ana Martín-VillalbaORCID

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Author profile →

3 papers

Recent·Most cited

iSCORE-PD: an isogenic stem cell collection to research Parkinson Disease

Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed, Pilar Álvarez Jerez, Jesse Dunnack, Riana Lo Bu, Yogendra Verma, Gabriella Rita Pangilinan, Annika Martin, Jannes Straub, YuXin Du, Vivien M. Simon, Steven Poser, Zipporiah Bush, Jessica Diaz, , Frank Soldner

The paper generates a collection of 65 isogenic human stem cell lines with PD-associated mutations to study Parkinson's disease, revealing that most genetic variation comes from cell culture rather than genome editing.

Nature Communications · Jun 17, 2026Peer-reviewedNeuroscience

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Manu Saraswat, Laura Rueda-Gensini, Elisa Heinzelmann, Tannia Gracia, Fani Memi, Grant de Jong, Jannes Straub, Cedar Schloo, Dirk C. Hoffmann, Erik Jung, Tim Kindinger, Bettina Weigel, Bryce Lim, Sophie Weil, Oliver Gould, , Moritz Mall

This study uses single-cell multiomics to identify regulatory programs and plasticity regulators in glioblastoma, revealing MYT1L as a key repressor of malignant plasticity.

bioRxiv · May 13, 2025 · PreprintCancer Biology

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

Lukas P. M. Kremer, Santiago Cerrizuela, Hadil El‐Sammak, Mohammad Eid Al Shukairi, Tobias Ellinger, Jannes Straub, Aylin Korkmaz, Katrin Volk, Jan Brunken, Susanne Kleber, Simon Anders, Ana Martín-Villalba

The paper uses single-cell triple-omics to show DNA methylation patterns are key to stemness in adult brain cells, especially under ischemic conditions.

Nature · Sep 4, 2024Peer-reviewedNeuroscience