Author

Jan Brunken

German Cancer Research CenterORCID 0000-0003-3292-9212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Ana Martín-VillalbaiD· 3 shared Simon AndersiD· 3 shared Susanne KleberiD· 2 shared A. Alshatwi Ali· 1 shared Ahmed SadikiD· 1 shared Andrea Sarvari· 1 shared Ângela GonçalvesiD· 1 shared Anna K. Marciniak-CzochraiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

Ana Martín-VillalbaORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 11, 2026

Inflammatory injury drives CIN and STING loss in polyploidpancreatic acinar cells

Jan Brunken, Enrico Frigoli, A. Alshatwi Ali…·Ana Martín-Villalba

The paper shows that inflammatory injury leads to polyploid pancreatic acinar cells with CIN and STING loss, contributing to tissue repair and cancer risk.

DOI 10.64898/2026.02.10.704772

mouseproteomics

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Cancer BiologyNature CommunicationsPeer-reviewedAug 6, 2025

Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression

Leo Carl Foerster, Oğuzhan Kaya, Valentin Wüst…·Ana Martín-Villalba

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

11 citations

humanmouse

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NeuroscienceNaturePeer-reviewedSep 4, 2024

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

Lukas P. M. Kremer, Santiago Cerrizuela, Hadil El‐Sammak…·Ana Martín-Villalba

The paper uses single-cell triple-omics to show DNA methylation patterns are key to stemness in adult brain cells, especially under ischemic conditions.

58 citationstop 1%

humanscRNA-seq

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