Daphne A. Superville

Tumor Heterogeneity Induces Pro- and Anti-metastatic Myeloid Cell Phenotypes in Breast Cancer Lung Metastasis

The paper profiles myeloid cells in breast cancer primary tumors and metastases to show how tumor heterogeneity drives shifts in myeloid cell phenotypes from anti- to pro-metastatic.

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.

CIT tumor lines: A novel series of immunogenic cutaneous squamous cell carcinoma cell lines derived from chemical carcinogenesis

The paper describes a new series of cSCC tumor lines that recapitulate human cSCC genetics and neoantigen patterns, enabling study of immunotherapy responses.