Brianna M. Lax

PRIZM uses low-N data and zero-shot models to rank protein variants, improving design efficiency with minimal experimental data.

This study uses zero-shot models to predict activity-enhancing mutations in fluorinase, leading to improved catalytic efficiency and stability in engineered variants.

The paper reports engineered sucrose synthase variants with enhanced activity and stability for efficient glycosylation, achieving high conversion yields and reduced environmental impact.