Victòria Gudiño

The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

TL1A-activated T cells remodel the rectal mucosa in Crohn's disease patients with perianal fistulizing disease

The paper identifies TL1A-driven cellular and transcriptomic changes in rectal mucosa of Crohn's disease patients with perianal fistulizing disease, revealing a novel TL1A-LT1{beta}2/IL-22 axis independent of TNF signaling.

Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis

The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.

Single Cell Integration Characterises Metaplasia in Inflammatory Intestinal Diseases

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.