Timothy F. Czajka

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication

The paper describes a biparatopic intrabody that protects Vero cells from ricin toxin by targeting two distinct epitopes on the toxin's enzymatic subunit, offering enhanced resistance compared to individual VHHs.

Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons

The paper develops fully human bifunctional anti-tau intrabodies that reduce intracellular tau and improve neuronal survival in disease-associated mutations.