David J. Vance

This paper identifies a conserved epitope on OspA that is broadly protective against multiple Borrelia genospecies, suggesting a basis for a universal Lyme disease vaccine.

This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.

The paper evaluates IgG reactivity to OspC-derived peptides in Lyme disease serum samples, identifying C10 as the most reactive epitope and highlighting complexities in B cell responses.

This study identifies a type-specific B cell epitope on OspC type A of Borreliella burgdorferi and shows its role in antibody-mediated motility inhibition.

The paper describes a biparatopic intrabody that protects Vero cells from ricin toxin by targeting two distinct epitopes on the toxin's enzymatic subunit, offering enhanced resistance compared to individual VHHs.

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.