Differential and regionally distinct molecular responses distinguish FLASH and conventional RT in a medulloblastoma model while preserving therapeutic outcomes
Michèle Knol, Javier Franco‐Pérez, Aymeric Almeida, Louis V. Kunz, Benoît Petit, Antoine Job, Jonathan Ollivier, Jackeline F. Romero, Jeannette Jansen, Veljko Grilj, Charles L. Limoli, Marie‐Catherine Vozenin, Paola Ballesteros‐Zebadúa
Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.
bioRxiv · Nov 1, 2026 · PreprintCancer Biology✦ In-depth digest