Charles L. Limoli

Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.

This study investigates FLASH-RT's neuroprotective effects by showing sustained AMPAR activation in CA3 neurons through early transcriptional upregulation of glutamate receptor genes.

This study investigates how modifying the microstructure of a CERN CLEAR-VHEE beam at the picosecond scale affects zebrafish embryo morphogenesis and hydrogen peroxide production.

This study uses MRI to differentiate between unirradiated mice and those exposed to conventional or FLASH radiotherapy, finding distinct brain changes after conventional but not FLASH treatment.

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.