metabolomics

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

UHPLC-MS/MS lipidomics of maize leaves (149 species, three genotypes, four growth stages, three leaf zones) shows genotype and leaf number explain most lipid variation.

A length- and mutation-load-corrected homoplasy screen of 1,813 MDR-TB genomes flags idsA2; its loss raises pretomanid MIC fourfold, delamanid and ethambutol twofold, via isoprenoid flux redirection.

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

Within 30 minutes, red light remodeled natural benthic diatom lipids and pigments more than blue; blue high light most altered photophysiology; de-epoxidation was similar at equal incident intensity.

A Biolink-compliant graph (∼15 million nodes, ∼113 million edges) adds RefMet and LIPID MAPS metabolite and lipid classifications, plus polygenic score and clinical data element entities, to Translator content.

VaLPAS pairs a bi-directional autoencoder with correlation for omics guilt-by-association with calibrated confidence; in L. starkeyi its autoencoder linked 176 unidentified metabolites to known-function proteins at ≥50% confidence.

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

SoLD, a leaf lipidomics resource (244 species) for the Sorghum Association Panel across two field trials, reveals low-input sulfoquinovosyldiacylglycerol depletion, triacylglycerol enrichment, and environment-specific GWAS loci.

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

Across seven pace-controlled outdoor overground speeds, healthy older adults (n=11) showed no higher gross or net walking cost than younger adults (n=16), trending lower instead.

Polyethylene glycol in human biofluids can mark drug exposure rather than contamination; it is oxidized to acid metabolites and appears in 2.3% of public metabolomics files.

Cyanochelin C, a non-acylated peptide siderophore from Atacama Desert Myxacorys chilensis, was fully stereochemically resolved; its gene cluster carries CcsQ, a putative deacylase from a cyanobacteria-specific, siderophore-linked acylase lineage.

In 76 healthy middle-aged women, daily bowel movements went with better composite cognitive scores, stronger gastric-phase to EEG-alpha coupling and higher faecal short-chain fatty acids than less-frequent ones.

In 110 common-garden Phragmites australis genotypes, effective salt stress left N, P and K resorption efficiency largely unchanged; efficiency instead tracked phylogeographic lineage, ecotype and latitude.

Tensile stretching of live, unfixed OVCAR8 cells on a fibronectin-functionalized double-network hydrogel expands them about 1.7x linearly, enabling single-cell MALDI metabolite imaging on unmodified commercial instruments.

Among 25 low-chlorophyll soybean mutants, a Lincoln mutant raised seed protein without yield loss, while Clark-derived Y11/y11 lowered seed oil alongside reduced pod gross photosynthesis.

Mecp2 knock-out mouse astrocytes accumulate cholesterol yet release poorly lipidated ApoE; cholesterol supplementation restores synaptic puncta density in neurons exposed to their conditioned medium and in Mecp2 heterozygous neurons.

Rat E. coli meningoencephalitis maps into ventricular, meningeal and perivascular niches: biofilm-like aggregates, aerobactin and salmochelin signals, calprotectin, neutrophil peptides, reduced proenkephalin peptides, with some markers recoverable in CSF.

Autocorrelation-aware bivariate Moran's I, bivariate Gaussian process tests and generalized additive models (R package sbivar) test cross-modality colocalisation on disjoint coordinates; many existing permutation tests inflate false positives.

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

TAFAZZIN-knockout C2C12 myoblasts show elevated proline catabolism into the TCA cycle alongside reduced collagen content, proline hydroxylation, crosslinking enzyme LOX, and proline incorporation into ECM proteins.

Re-annotated MitoCore (SBML3, UniProt, EC, Human-GEM gene rules) supports sMOMENT proteomics integration, reducing thrombocyte ATP prediction error by 89% relative to the original model.

OmicsPred collects 3,339,469 genetic prediction models for transcript, protein and metabolite traits with harmonised metadata and MetaXcan/PGSC-Calculator files, plus multi-ancestry Million Veterans Program phenome-wide association results.

Empagliflozin lowered renal norepinephrine by about 50% in rats with heart failure, independent of intrarenal renin-angiotensin activity, and shifted kidney macrophages toward a reparative phenotype.

A gut consumer-resource model with explicit metabolic pathways yields competition-dominated healthy and cooperation-dominated dysbiotic states; an interaction-balance index (ENBI) detects this shift in human disease cohorts.

Domestic cat kidneys hold more Oil Red O-stained lipid than dog kidneys, and their tubular droplets carry a less-polar band containing ether-linked lipids resembling monoalkyldiacylglycerols.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

Multi-omic profiling of unicellular Mesotaenium and filamentous Zygnema under osmotic and salt stress reveals a conserved protein and cell-wall remodeling chassis driving acclimation in land plants' closest algal relatives.