Phylogenomic screening reveals idsA2 loss conferring nitroimidazole cross-resistance in Mycobacterium tuberculosis
Yu Zhang, Xinchang Chen, Shiyong Wang, Qian Wu, Yuchang Di, Weifang Lin, Wenya Hua, Xuelian Zhang, Ning Jiang, Wenhong Zhang, Jiazhen Chen
A length- and mutation-load-corrected homoplasy screen of 1,813 MDR-TB genomes flags idsA2; its loss raises pretomanid MIC fourfold, delamanid and ethambutol twofold, via isoprenoid flux redirection.
bioRxiv · Oct 24, 2026 · PreprintPathology✦ In-depth digest