Craig W. Lindsley

Broad Cognitive and Motivational Enhancement through M4-Selective Muscarinic Modulation

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

Targeting Protease-activated Receptor 4 (PAR4) Protects Against Acute Kidney Injury (AKI) in Ischemia Reperfusion Injury

This study shows that PAR4 antagonism reduces AKI severity and improves survival in an IRI mouse model.

The importance of M1 muscarinic receptor phosphorylation in learning and memory

This study shows that M1 receptor phosphorylation is critical for contextual memory but not cued memory, and biased Gq signaling alone is insufficient for restoring contextual memory.

Cryo-EM reveals a new allosteric binding site at the M5 mAChR

The paper presents a cryo-EM structure of the M5 mAChR with a novel allosteric binding site identified through mutagenesis, pharmacology, and simulations.

Astrocytes expressing M4 muscarinic acetylcholine receptor regulate locomotion and survival in murine prion disease

The paper identifies a subpopulation of M4 mAChR-expressing astrocytes that regulate locomotion and have a detrimental effect in murine prion disease.

Rostral Pedunculopontine Nucleus Infusion of M4 Positive Allosteric Modulator VU0467154 Augments L-DOPA Effects in Hemiparkinsonian Rats

This study investigates the effect of M4 receptor activation in the pedunculopontine nucleus on L-DOPA-induced dyskinesia and motor function in hemiparkinsonian rats.

The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST

This study investigates how mGlu3 NAM pretreatment affects behavioral and molecular changes in the insular cortex and BNST after predator odor exposure in rats.

Effects of acute and repeated administration of the selective M4 PAM VU0152099 on cocaine vs. food choice in male rats

This study examines the effects of repeated M4 PAM VU0152099 administration on cocaine vs. food choice in rats, finding progressive suppression of cocaine choice without rebound or lasting effects.

Activation of M1 muscarinic receptors reduce pathology and slow progression of neurodegenerative disease.

This study shows that activating M1 muscarinic receptors with VU846 slows murine prion disease progression, reduces neuroinflammation, and preserves synaptic proteins.

Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity

The paper shows that phospholipase D is essential for M1 PAM-induced long-term depression in rodent prefrontal cortex, and biased M1 PAMs that do not activate PLD have distinct effects on cortical plasticity.