Posttraumatic Stress Disorder Research

Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program

This paper conducts a large-scale epigenome-wide association study of PTSD in the Million Veteran Program, identifying 272 CpG sites associated with PTSD traits and replicating prior findings.

Striatal habit system drives behavioral rigidity in PTSD

This study investigates how striatal-mediated habits contribute to behavioral rigidity in PTSD compared to trauma-exposed controls.

Rare copy number variation in Post-traumatic stress disorder using whole genome sequencing and biobank data

This study investigates rare copy number variants in PTSD using whole-genome sequencing and biobank data, finding significant associations in specific ancestry groups and gene-sets.

Circulating Lipids are Associated with PTSD Severity and Predict Symptomatic PTSD in a Cohort of Veterans and Service Members

This study identifies five circulating lipids associated with PTSD severity and shows they can distinguish symptomatic PTSD patients from asymptomatic controls.

Altered Dorsolateral Prefrontal Glutamate Dynamics During Working Memory in Trauma-Exposed Individuals With and Without PTSD: A 7T Functional Magnetic Resonance Spectroscopy Study

This study uses 7T fMRS to examine DLPFC glutamate dynamics during working memory in PTSD, trauma-exposed, and non-trauma-exposed individuals, finding altered glutamate levels and cognitive performance differences.

Stress-coping behavior during predator odor exposure is associated with differences in decision making

This study links stress-coping behaviors during predator odor exposure to changes in decision-making in rats, showing correlations with impulsive choice and reward-related behaviors.

Dissociable Neural Responses to Conditioned Social Threats are Modulated by Spatial Proximity in PTSD and MDD

In 50 trauma-exposed veterans, thalamic hypoactivity to near virtual-reality threats tracked both PTSD and MDD severity, while amygdala hyperactivity to far threats tracked only PTSD severity.

Temporal Trajectories of Motor and Cognitive Dysfunction After Combined PTSD and TBI in Mice: Implications for Neurodegenerative Disease Vulnerability

This study examines the temporal effects of combined PTSD and TBI in mice, revealing sex- and time-dependent behavioral deficits.

Transdiagnostic Neurobiological Biotypes of Trauma Timing: Data-driven approach of Childhood and Adulthood-Onset Trauma

The paper uses data-driven clustering to identify distinct neurobiological profiles associated with childhood-onset trauma (CT) and adulthood-onset trauma (AT) based on resting-state functional connectivity.

Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD

This study identifies PAI-1 as a blood biomarker and brain risk factor for PTSD, showing increased levels in PTSD-like models and soldiers with PTSD symptoms.

Prefrontal Cortical Deficits are a Putative Susceptibility Factor for PTSD

The paper investigates prefrontal cortical deficits as a potential susceptibility factor for PTSD using an animal model and human data, finding mPFC dysfunction before trauma in susceptible individuals.

Post-traumatic stress symptoms are associated with altered cognitive circuits and threat pathways in chronic pain

This study investigates how post-traumatic stress symptoms (PTSS) affect brain networks related to working memory and threat processing in chronic pain patients, finding altered prefrontal and brainstem connectivity linked to depression and pain catastrophizing.

Pretrauma cognitive traits predict trauma-induced fear generalization and associated prefrontal functioning in a longitudinal model of posttraumatic stress disorder

The paper identifies pretrauma cognitive traits predicting trauma-induced fear generalization and prefrontal cortex changes in a rat model of PTSD.

The Genetic Relationships Between Post-Traumatic Stress Disorder and Its Corresponding Neural Circuit Structures

This study identifies genetic links between PTSD and brain circuitry traits using GWAS meta-analysis and multiple genetic methods, finding shared loci and causal relationships.

Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology

The paper examines thalamic volume differences in trauma-exposed individuals with PTSD, MDD, and controls, finding specific volume reductions and associations with symptom severity and childhood trauma.

Transcriptional changes across tissue and time provide molecular insights into a therapeutic window of opportunity following traumatic stress exposure

The paper examines transcriptional changes across tissues and time after traumatic stress exposure in rats to identify intervention windows for preventing adverse neuropsychiatric outcomes.

Impaired context disambiguation as a key determinant of post-traumatic psychopathology: A neurocomputational account

This paper develops a neurocomputational model of PTSD by linking Bayesian belief-updating and active inference to impaired context disambiguation and maladaptive behavior.

Temporal Immune Effects of Oral Ketamine on PTSD: Transcriptomic Evidence of Short-Term Inflammation Suppression and Long-Term Immune Remodelling

This study examines the short- and long-term transcriptomic effects of oral ketamine on PTSD, revealing inflammation suppression and immune remodelling through gene expression analysis.

Methylome and transcriptome functional analysis identifies key biomarkers in ketamine's sustained therapeutic effect on PTSD

This study identifies key methylomic and transcriptomic biomarkers predictive of sustained ketamine response in PTSD by comparing responders and non-responders.

Epigenome-wide association study of posttraumatic stress disorder in a South African population

This study conducts an epigenome-wide association study of PTSD in a South African population, identifying epigenetic changes and accelerated DNA methylation age associated with PTSD severity and comorbid metabolic syndrome.

Posttraumatic reexperiencing and alcohol use: mediofrontal theta as a neural mechanism for negative reinforcement

This study investigates the neural mechanisms linking PTSD symptoms and heavy alcohol use in veterans, finding altered mediofrontal theta responses associated with negative reinforcement.

Evidence for distinct networks underlying symptom clusters of posttraumatic stress disorder

The paper identifies two distinct brain networks associated with different PTSD symptom clusters using lesion-behavior mapping in combat veterans with traumatic brain injuries.

Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAP

This study investigates sex-specific effects of PACAP in a PTSD model, finding differential behavioral outcomes in male and female rats following stress.

Decoding the transcriptomic signatures of psychological trauma in human cortex and amygdala

The paper investigates transcriptional signatures of trauma in human brain regions using RNA-seq data from 304 donors, identifying differential vulnerability of cortical and amygdala regions to different trauma types.

Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder

The paper identifies endocannabinoid and neuroplasticity-related changes in a rat PTSD model that distinguish susceptible from resilient individuals.

Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis

This study shows that both direct and witnessed trauma reduce allopregnanolone levels and impair fear regulation in mice, suggesting neurosteroid deficits contribute to PTSD-like behaviors.

The lipidome of posttraumatic stress disorder

This study analyzes the lipidome of PTSD patients and trauma-exposed non-PTSD individuals, finding sex-specific lipid subclass alterations linked to PTSD severity and health outcomes.

Pre-trauma memory contextualization as predictor for PTSD-like behavior in male rats

This study investigates if pre-trauma memory contextualization predicts PTSD-like behavior in rats, finding a negative relationship only in a non-stress group.

Prefrontal metabolite alterations in individuals with posttraumatic stress disorder: a 7T magnetic resonance spectroscopy study

This study uses 7T MRS to find lower glutamate levels in PTSD and trauma-exposed individuals compared to controls, with additional changes in NAA and lactate, and a link between glutamate and depression symptoms.

Neural patterns differentiate traumatic from sad autobiographical memories in PTSD

This study identifies distinct neural patterns in PTSD patients for traumatic versus sad memories, showing divergent hippocampal representations and symptom severity effects in the posterior cingulate cortex.