Benjamin A. Packard

Adolescent Stress Exposure: Behavioral Consequences and Molecular Mechanisms in Corticolimbic Networks

This study investigates the long-term behavioral and molecular effects of adolescent chronic variable stress in rats, revealing sex- and region-specific changes in corticolimbic circuits.

Projections from subfornical organ to infralimbic cortex modulate carbon dioxide associated fear

This study identifies a neural circuit involving the subfornical organ and infralimbic cortex that modulates fear responses to carbon dioxide, linking interoceptive signals to fear behavior.

Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAP

This study investigates sex-specific effects of PACAP in a PTSD model, finding differential behavioral outcomes in male and female rats following stress.

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbuminpositive Interneurons Attenuates Chronic Stress Adaptions in Male Mice

This study inhibits prefrontal cortex parvalbumin interneurons in mice using DREADDs and shows that it reduces chronic stress-related behaviors and physiological changes.

Prefrontal Cortex Regulates Chronic Stress-Induced Cardiovascular Susceptibility

This study shows that reducing glutamate release from infralimbic cortex neurons increases cardiovascular reactivity and vascular dysfunction under chronic stress.

Selective modulation of the glucocorticoid receptor with CORT108297 during chronic adolescent stress evokes sex specific effects in adulthood.

This study examines how adolescent chronic stress affects behavior and physiology differently in male and female rats, with GR signaling playing a role in some outcomes.

Use of CRISPR/Cas9 Gene Targeting to Conditionally Delete Glucocorticoid Receptors in Rat Brain

This study uses CRISPR/Cas9 to create a conditional GR knockout in rats, showing sex-specific behavioral effects of GR deletion in the prelimbic cortex.