Topic · Pharmacology · Pharmacology, Toxicology and Pharmaceutics

Pharmacogenetics and Drug Metabolism

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Pharmacology & Toxicology·bioRxivPreprint·Jun 20, 2026
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Chemical augmentation of the validated HepaRGTM CYP induction test method Part 2: Additional laboratory study supported by mRNA analysis
Emma Quartermain, Jinkang Zhang, Tim H. Marczylo…+1 more author·Miriam Naomi Jacobs
A third laboratory transferred the HepaRG CYP induction assay to six augmentation and four additional non-pharmaceutical chemicals; parallel mRNA data supported enzyme activity calls, with CYP3A4 most concordant.
2 citations
human·bulk RNA-seq
Bioinformatics·Nucleic Acids ResearchPeer-reviewed·Oct 23, 2020
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Integration of the Drug-Gene Interaction Database (DGIdb) with open crowdsource efforts
Sharon L. Freshour, Susanna Kiwala, Kelsy C. Cotto…+5 more authors·Alex Handler Wagner
DGIdb 4.0 aggregates drug-gene interaction and druggability claims from 41 sources, adding crowd-sourced Drug Target Commons, Wikidata-based drug normalization, search-relative query scores, and NDEx export.
1,003 citationstop 1%
human·statistical model