Topic · Biomedical Engineering · Engineering

Advanced optical system design

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

A rapid, low-cost approach to solid immersion lens fabrication for enhanced resolution in optical microscopy

Liam M. Rooney, Jay L. Christopher, Shannan Foylan, Charlie Butterworth, Laura S. Copeland, Lewis D. Walker, Katie Coubrough, Gwyn W. Gould, Margaret Cunningham, Ralf Bauer, Gail McConnell

This paper presents a low-cost, rapid method to fabricate solid immersion lenses (SILs) that enhance optical microscope resolution, achieving performance comparable to commercial glass SILs at a fraction of the cost.

bioRxiv · Feb 20, 2026 · PreprintBiophysics

A large 3D-printed integrated lens-biprism element enhances contrast in transmission stereomicroscopy

Liam M. Rooney, W. B. Amos, Shannan Foylan, Jay L. Christopher, Charlie Butterworth, Ralf Bauer, Gwyn W. Gould, Gail McConnell

The paper introduces a 3D-printed lens-biprism element that improves image contrast in stereomicroscopy by enhancing illumination uniformity.

Microscopy and Microanalysis · Sep 3, 2025Peer-reviewedBiophysics

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Fabian F. Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L. Hotz, Lachlan W. Whitehead, Armin Bahl, Stephan C. F. Neuhauss, Alard F. Roebroeck, Esther T. Stoeckli, Soeren S. Lienkamp, Adriano Aguzzi, Fritjof Helmchen

The paper introduces a novel Schmidt objective for high-resolution imaging in cleared tissues, achieving high NA, long WD, and large FOV with only two optical elements.

Nature Biotechnology · Mar 30, 2023Peer-reviewedNeuroscience