Cancer-related cognitive impairment studies

Cognitive Control in Pediatric Cancer Survivors: A task-fMRI study

This study uses fMRI to compare brain activation during a cognitive task between pediatric cancer survivors exposed to chemotherapy and healthy controls, finding altered neural activation and cognitive control deficits in the chemo-exposed group.

Extracellular Vesicles Derived from L-MYC Neural Stem Cells Mediate Neuroprotection in 3D Models of Chemotherapy- and Radiation-Induced Neurotoxicity

This study uses a 3D neural tissue model to show that extracellular vesicles from L-Myc neural stem cells promote recovery from chemotherapy- and radiation-induced neurotoxicity by modulating inflammatory and stress pathways.

Microglia transcriptomic response to doxorubicin-induced genotoxic stress

This study investigates the transcriptomic response of human microglia to doxorubicin, identifying gene expression changes and pathways involved in neurotoxicity.

Environmental factors contribute to cancer therapy toxicity

This study shows that housing facility and time of day affect MTX-induced chemotoxicity in mice through changes in gut microbiome and inflammatory responses.

C5aR1 inhibition alleviates cranial radiation-induced cognitive decline

This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.

Human-dose equivalent 5-fluorouracil triggers a pathophysiological cascade of neuroinflammation, cortical remodeling, and behavioural disruption in Wistar rats.

This study shows that 5-fluorouracil causes dose-dependent neurotoxicity in rat cerebral cortex, including behavioral deficits, oxidative stress, neuroinflammation, and histological changes.

Behavioral profiling of hyperbaric oxygen as an intervention for chemotherapy-related functional impairments in male and female mice

This study examines the effects of hyperbaric oxygen (HBO) on chemotherapy-induced cognitive impairments in mice, showing some improvement in specific behaviors but also unexpected negative effects.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

Associations between DNA methylation and cognitive function in early-stage hormone receptor-positive breast cancer patients

This study identifies DNA methylation sites associated with cognitive function in early-stage hormone receptor-positive breast cancer patients using epigenome-wide association analyses.

Dynamin-1 is a potential mediator in Cancer-Related Cognitive Impairment

This study investigates the role of Dynamin-1 in cancer-related cognitive impairment using human and animal models, finding that DNM1 downregulation is associated with cognitive impairment onset.

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences

This study shows that riluzole improves cognitive function and reduces neurodegeneration in mice after cranial radiation therapy by increasing BDNF levels and reducing neuroinflammation.

Systemic and targeted activation of Nrf2 reverses doxorubicin-induced cognitive impairments and sensorimotor deficits in mice

This study shows that Nrf2 activators reverse doxorubicin-induced cognitive and motor impairments and brain structural changes in mice.

Cisplatin Induces BDNF Downregulation in Middle-Aged Female Rat Model while BDNF Enhancement Attenuates Cisplatin Neurotoxicity

This study shows cisplatin reduces BDNF in middle-aged female rats and impairs cognition, while BDNF enhancement protects neurons but may affect cancer cell viability.

Long-Term Oral Tamoxifen Administration Decreases Brain Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats

This study shows that long-term oral tamoxifen reduces BDNF in the hippocampus of female rats, suggesting a potential mechanism for cognitive side effects in patients.

PAK3 downregulation induces cognitive impairment following cranial irradiation

This study shows that PAK3 downregulation caused by cranial irradiation leads to cognitive impairment, which can be reversed by antagomiR-206-3p.

Genetic variants associated with longitudinal cognitive performance in older breast cancer patients and controls

This study identifies genetic variants associated with cognitive decline in older breast cancer patients compared to controls using longitudinal cognitive data.

Dietary zinc protects against methotrexate-induced neurotoxicity in rats via modulation of oxidative stress, inflammation and neuronal energy metabolism

This study shows dietary zinc reduces methotrexate-induced neurotoxicity in rats by improving oxidative stress, inflammation, and neurotransmitter levels.

Letrozole delays acquisition of water maze task in female BALB/c mice: possible involvement of anxiety

This study examines the effects of letrozole on cognitive behavior in female BALB/c mice, finding dose-dependent impacts on learning and memory tasks.

Brain Connectivity Tracks Effects of Chemotherapy Separately from Behavioral Measures

The paper examines how chemotherapy affects brain connectivity and cognitive health, finding that functional connectivity changes are distinct from behavioral measures of cognitive performance.

Acute memory deficits in chemotherapy-treated adults

This study investigates acute memory deficits in chemotherapy-treated adults, finding accelerated forgetting and increased intrusions after treatment.