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This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

This paper develops a DNA hydrogel that rapidly stops bleeding and promotes tissue regeneration in mice by combining hemostasis with bioactive properties.

This study demonstrates hydrogen-driven cofactor regeneration for efficient pyruvate-to-lactate conversion using engineered enzymes.

This study evaluates the risk of a recombinant plant rhabdovirus, MMV-GFP, compared to its wildtype MMV-WT, finding it less fit and posing no greater risk to crops or ecosystems.

This study shows how PEG hydrogel formulation affects the accumulation of proteins and nanoparticles, with larger molecules requiring more permissive formulations.

ContiDesigner is a tool for designing continuous fermentation cascades that identifies optimal operating conditions to maximize productivity.

This paper demonstrates the biosynthesis of diverse retinal analogues in engineered E. coli using Blh, a carotenoid cleavage enzyme, through substrate promiscuity and structure-guided engineering.

The paper quantifies variability in temporal interference simulations caused by non-deterministic mesh generation and shows that multi-run averaging reduces this noise.

This paper introduces a closed-loop optical platform for precise retinal stimulation in mice, achieving high-resolution patterned stimulation with real-time focus correction.

This study shows HYAL1 suppression in glioma cells increases invasion by altering ROS levels and adhesion molecule expression in 3D hyaluronic acid matrices.

This paper develops nanodiscs for targeted delivery of an anti-inflammatory drug to macrophages in AAA, showing reduced disease progression in mice.

This study develops submicron phosphatidylserine-exposing polymeric particles (PSPs) that modulate macrophage activity by reducing inflammation and promoting resolution through redox adaptation and suppression of inflammatory signaling.

This paper develops a colorimetric hydrogel dressing that uses a smartphone camera to monitor wound pH in real-time, enabling point-of-care diagnostics for chronic wounds.

This paper develops a closed-loop vibrotactile stimulation system to reduce tremor amplitude and propranolol use by modeling a nonmonotonic tremor-vibration relationship.

The study tests if a crossmodal congruency task can measure the intuitiveness of sensory feedback in lower limb prostheses, finding it effective at the knee but not the foot.

This study shows that sustained volumetric compression of breast cancer cells induces a jammed state, which primes them for enhanced migration and invasion after recovery.

This paper develops a multiscale computational model of pulmonary vascular remodeling in PH, showing it can predict pressure, wall thickness, and stiffness changes in response to treatment.

This paper introduces a topology-based framework to describe near-wall hemodynamics in cerebral aneurysms, identifying tornadic-like fluid structures linked to aneurysm pathology and validated using 4D flow MRI.

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

FLIP2 adds seven protein fitness datasets and 16 splits for enzymes, light-sensitive proteins, and interactions; simple ridge and zero-shot baselines often rival fine-tuned protein language models.