A Time-Resolved Single-Cell Atlas Reveals Infection-Status, Age-, and Sex-Dependent Immune Responses Drive Viral Disease Severity
Lujia Chen, Anchen Qiu, JooYoung Kim, Nebal Abu Hussein, Mengyao Lu, Karen Agaronyan, Kexin Sun, Yifan Yuan, Amy Zhao, Gagan Heda, Xinghua Lu, Georgios D. Kitsios, Alicia N. Rizzo, William Bain, Toru Nyunoya, , Lokesh Sharma
This study uses time-resolved single-cell RNA sequencing in mice to show age and sex influence immune responses and viral disease severity through altered gene expression and inflammation.
bioRxiv · Aug 11, 2026 · PreprintImmunology