Discover, rate, and discuss biology preprints.

mock-fastq-generator creates synthetic FASTQ files for testing bioinformatics pipelines without using biological data.

This study demonstrates that mobile CRISPR-Cas9 tools can effectively prevent the dissemination of an AMR plasmid from K. pneumoniae to E. coli under various experimental conditions.

This study identifies phosphatidylserine receptors as critical for CCHFV infection and shows that targeting these receptors can protect against viral disease.

This study examines how different dietary fibre regimes affect the gut microbiome, SCFA profiles, and immune responses in zebrafish, showing context-specific effects influenced by sex and dietary context.

This study links spinal cord stimulation periodicity to artificial sensory perception by identifying spike-count regimes that shape detection and discrimination behavior in rodents.

This paper develops ROS-scavenging microparticles for sustained EPO release to treat glaucoma neurodegeneration, showing neuron preservation in animal models.

The paper identifies transcriptionally distinct muscle nuclei in fetal chicken limb muscles, showing tip and central domain identities and signaling roles in muscle development.

This paper evaluates a single-plane electrical impedance tomography framework for assessing liver and kidney health, finding it feasible and effective for multi-organ evaluation.

The paper compares splenic and lymph node antibody-secreting cells in Trypanosoma cruzi infection, finding distinct transcriptional, phenotypic, and functional profiles.

This study shows RTEL1 ATPase activity is essential for both telomere strand synthesis and TERT regulation, with reduced TERT providing an adaptive survival mechanism in RTEL1-defective cells.

The paper identifies environmental factors and growth stages affecting fibre yield and quality in rain-grown cotton using statistical models and field data.

This study shows that lipid droplet formation in pulmonary microvascular endothelial cells protects against hemin-induced inflammation and cell death.

This study uses molecular dynamics simulations to show that open-state GBP1 and GBP2 require specific membrane environments to remain stable on bacterial membranes.

The paper analyzes allopolyploidization events in Brettanomyces bruxellensis using graph pangenomes to identify structural variants and their functional impacts.

This paper establishes a robust workflow for injector-based pump-probe TR-SSX at the MicroMAX beamline to study CrPhotLOV1 structural dynamics.

The paper investigates how combinations of Nav1.7 and Nav1.8 channels affect nociceptor excitability, showing that their synergistic effects vary across neuronal subtypes.

The paper identifies converging molecular pathways in genetic epilepsies through network analysis of epilepsy-associated genes and highlights potential therapeutic targets.

This study demonstrates that a single-AAV vector delivering the SpCas9 nickase and sgRNA achieves greater CAG/CTG repeat contraction in a Huntington's disease mouse model compared to a dual-vector system.