Arthur J. Zaug

This study shows RTEL1 ATPase activity is essential for both telomere strand synthesis and TERT regulation, with reduced TERT providing an adaptive survival mechanism in RTEL1-defective cells.

This study evaluates thiomorpholino antisense oligonucleotides (TMOs) as telomerase inhibitors, showing they reduce telomerase activity and limit cancer cell proliferation.

The paper examines the expression patterns and functional relationships of human vault RNA paralogs through knockout experiments in cell lines, suggesting potential functional connections but no clear biological roles.

This study identifies a misfolded CR4/5 conformation in hTR that is not required for hTERT binding and is detrimental to telomerase activity.