Author

Darren J. Hart

Centre National de la Recherche ScientifiqueORCID 0000-0002-3502-2002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alberto Florez PradaiD· 3 shared Camile Bourgneuf· 1 shared Catherine IseliD· 1 shared Chantal PichoniD· 1 shared Chloé SturmachiD· 1 shared Didier BoturyniD· 1 shared Guido UguzzoniiD· 1 shared Nabila LarouiiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioinformatics

Alberto Florez PradaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioinformaticsSoftwareXPeer-reviewedOct 30, 2026

mock-fastq-generator: A synthetic FASTQ generator

Alberto Florez Prada, Darren J. Hart

mock-fastq-generator creates synthetic FASTQ files for testing bioinformatics pipelines without using biological data.

DOI 10.1016/j.softx.2026.103175

whole-genome sequencingsimulation

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MicrobiologybioRxivPreprintJul 31, 2026

Affinity-enhanced peptides delivered by mRNA-LNPs inhibit influenza A virus replication by disrupting the PA-PB1 interaction

Alberto Florez Prada, Chloé Sturmach, Nabila Laroui…·Darren J. Hart

The paper identifies and delivers peptides that disrupt the PA-PB1 interaction in influenza polymerase, inhibiting viral replication in cultured cells.

DOI 10.64898/2026.07.29.740963

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJun 18, 2026

Calculation of sequence space coverage in a mutagenesis library

Alberto Florez Prada, Guido Uguzzoni, Darren J. Hart

This paper introduces a scalable algorithm to calculate exact discovery probabilities in mutagenesis libraries and provides an open-source tool for experimental design.

DOI 10.64898/2026.06.15.729752

statistical modelbenchmarking

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