mock-fastq-generator: A synthetic FASTQ generator
Alberto Florez Prada, Darren J. Hart
mock-fastq-generator creates synthetic FASTQ files for testing bioinformatics pipelines without using biological data.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Alberto Florez Prada, Darren J. Hart
mock-fastq-generator creates synthetic FASTQ files for testing bioinformatics pipelines without using biological data.
Taylor J Tvrdy, Aditi Bhattacharya, Rahul Radhakrishna…·Amol P. Yadav
This study links spinal cord stimulation periodicity to artificial sensory perception by identifying spike-count regimes that shape detection and discrimination behavior in rodents.
Qian Feng, Pierce Rafter, Iain Wilson…·Warren C. Conaty
The paper identifies environmental factors and growth stages affecting fibre yield and quality in rain-grown cotton using statistical models and field data.
Victor Loegler, Anne Friedrich, Joseph Schacherer
The paper analyzes allopolyploidization events in Brettanomyces bruxellensis using graph pangenomes to identify structural variants and their functional impacts.
Dmytro V. Vasylyev, Sidharth Tyagi, Mohammad‐Reza Ghovanloo…·Stephen G. Waxman
The paper investigates how combinations of Nav1.7 and Nav1.8 channels affect nociceptor excitability, showing that their synergistic effects vary across neuronal subtypes.
Malay Chaklader, Guilherme Henrique Souza Bomfim, Jiankun Zhu…·Beverly A. Rothermel
This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.
Sunil Kumar Dogga, Jesse Rop, Alex Makunin…·Mara Lawniczak
The paper generates high-quality chromosome-level genomes for three Plasmodium species from natural infections, improving understanding of their biology and evolution.
Tomomi Sato, Kaito Saito, Tsubasa Oyu…·Masabumi Nagashima
This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.
The paper examines immune suppressive gene expression in normalized breast cancer endothelial cells and finds similarities with healthy human endothelial cells.
Joy S. Xiang, Karen X. Zhao, Laliv Tadri…·Gene Wei-Ming Yeo
This study maps SARS-CoV-2 protein-RNA interactions using eCLIP, revealing new regulatory sites for viral replication and translation.
Daniel Müller‐Komorowska, Tomoki Fukai
This study uses simulation-based inference to quantify compensatory mechanisms in a spiking neuronal network model under hyperexcitability conditions.
Nabeel S. Ganem, Dean Light, Roni Haas…·Ayelet T. Lamm
This study shows ADARs prevent RNAi from targeting self-produced dsRNA by reducing siRNA production and interfering with RNAi processing in C. elegans.
Jiao Cao, Jun Zeng, Yiwei Meng…·Chaoyong James Yang
Decoder-FFPE-seq improves sensitivity and resolution for spatial transcriptomics in FFPE tissues, enabling analysis of rare genes and tumor microenvironments.
Guodong Rao, Zheng Zhang, Xin Liu…·Yang Yang
This study uses EPR and ENDOR spectroscopy along with DFT to show how protein scaffolds alter the electronic structure of a ketyl radical intermediate in TPP-dependent radical biocatalysis, affecting enzyme reactivity.
Kartikeyan Premrajka, Ulrike Johnsen, Holger Preidel…·Marc Bramkamp
This study identifies HpaAB as an active chromosome segregation system in Haloferax volcanii, essential for equipositioning replicons and maintaining genomic stability.
Giovanni Pellegrino, Gian Marco Duma, Anna‐Lisa Schuler…·Javier Rasero
This study evaluates ten excitability metrics from MEG data to show cortical excitability is multidimensional with distinct spatial and functional patterns.
Morgane Vandendoren, Jason G Landen, Joseph F Rogers…·Adam C. Nelson
The paper shows PVNOT neurons drive transitions from rest to thermogenesis and behavioral arousal in both social and non-social contexts in mice.
Edgar González-Buendía, Havva Ortabozkoyun, Danny Reinberg
This study identifies a functional interaction between PDS5A and TOP2B at CTCF-bound chromatin sites, showing their cooperative recruitment and impact on gene expression and chromatin structure in gliomas.
Keely E.A. Oldham, Suyan Yee, Kai Xun Chan, Peter D. Mabbitt
The paper introduces synthetic tools to redirect and chemically control the Arg/N-degron pathway by modifying PRT1's substrate recognition and using nanobodies to induce ubiquitination.
Arlind B. Mara, Angela Makumi, Rosemary Grace Ozyck…·Steven J. Geary
This study identifies host transcriptional changes during different stages of Mmm infection in cattle, revealing immune and tissue remodeling pathways involved in lesion progression.