Peter D. Mabbitt

The paper introduces synthetic tools to redirect and chemically control the Arg/N-degron pathway by modifying PRT1's substrate recognition and using nanobodies to induce ubiquitination.

This study investigates the molecular basis and evolutionary constraints of organophosphate resistance in dipteran carboxylesterases, revealing sequence context-dependent success of a mutation and trade-offs between affinity and turnover.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.