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This study identifies PSMC2 overexpression as a driver of bortezomib resistance in multiple myeloma and shows that combining p97 inhibition with bortezomib overcomes this resistance.

This paper introduces a non-equilibrium theory of sensory perception using activity flows in cortical columns, showing that small-number fluctuations are essential for effective representation.

FoXSight identifies weak binding events in crystallographic fragment screening by detecting target-specific density features in noisy electron density maps.

This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.

This study identifies structural features of Hmg2 that mediate GGPP-dependent misfolding and regulation, revealing that GGPP binding occurs in the transmembrane domain and loops in the lumenal domain transmit the response.

This study uses OPM-MEG to show 2-3 month-old infants can distinguish happy and angry prosody in natural sentences, with neural discrimination occurring 346-454 ms after sentence onset.

This study analyzes ancient U/V sex chromosomes in Polytrichaceae mosses, showing that recombination suppression has limited SDR expansion and functional degeneration despite their 124 million-year-old origin.

This study shows that PEA-coated monetites functionalized with fibronectin and low-dose rhBMP-2 promote structurally mature bone regeneration in critical-sized defects.

The paper identifies AC-to-V1 projecting neurons in mice and shows they have distinct audiovisual responses independent of motor activity.

This paper introduces a microfluidic platform for applying multiaxial mechanical loading to cell-laden scaffolds, demonstrating its ability to promote cardiac tissue organization and contractile activity.

This study investigates how herboxidiene affects EGFR expression and proliferation in A172 glioblastoma cells, finding that it inhibits growth without causing intron 2 retention seen in lung adenocarcinoma cells.

This study examines how C. glutamicum cells respond to pH stress by tracking cell size and survival, revealing stochastic and heritable differences in acid and alkaline stress survival.

This study shows that sodium arsenite requires additional mitochondrial or redox stress to cause dopaminergic neurotoxicity in C. elegans, but not fluoroacetic acid.

This study shows that macaque hand choice and reaction time are influenced by target position, hand displacement, head rotation, and gaze direction, similar to human behavior.

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

This study tests TRPV4 antagonism in a pig model of post-hemorrhagic hydrocephalus, showing it prevents ventriculomegaly and reduces intracranial pressure.

This study shows that implicit recalibration becomes flexible after prolonged training on novel sensorimotor mappings, allowing context-specific adaptation.

This study shows CD40L and IFN-γ induce inflammation and neurodegeneration in human stem cell-derived microglia, suggesting CD40L blockade as a potential MS therapy.