CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models
Timothy Hammond, Gregory S. Wirak, Sean K. Ryan, Anna Blazier, Dongyu Liu, Ivan Nyarko-Danquah, Michael LaMorte, Shameer Khader, Jose Vela, Bo Yang, Hendrik Wesseling, Bailin Zhang, Frank Rapaport, Roopali Gandhi, Biljana Djukic, Dimitry Ofengeim
This study shows CD40L and IFN-γ induce inflammation and neurodegeneration in human stem cell-derived microglia, suggesting CD40L blockade as a potential MS therapy.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience