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This study compares hidden Markov models (HMMs) and vector autoregressive (VAR) models in resting-state fMRI to determine if apparent state transitions reflect discrete dynamics or continuous activity, finding that VAR often outperforms HMMs in continuous cases.

This study shows that 40 Hz visual stimulation increases gamma-band functional connectivity between visual, parietal, and frontal regions, with the visual-parietal connection being most significant.

Protify benchmarks protein language models across tasks and evaluation settings, revealing task dependence and homology leakage in model performance.

This study characterizes the MHC genomic architecture in the Midas cichlid using integrated genomic and transcriptomic analyses, revealing gene diversity, evolutionary patterns, and tissue-specific expression.

The paper proposes a Latent Cell-State Model to reconstruct cellular trajectories by inferring hidden cell states and generating gene expression profiles at unobserved timepoints.

This study shows that acute nicotine exposure induces a spatially organized transcriptional response in mouse olfactory cortex, affecting specific neurons and their surrounding astrocytes.

The paper compares transcriptomic profiles across kidney organoid, assembloid, and transplantation models to evaluate their maturity and suitability for research.

TRACE provides a framework for creating traceable biomedical resources, demonstrated with a single-cell glaucoma dataset, enabling reproducible analyses and resource reuse.

The paper quantifies developmental variation in C. elegans natural populations using embGAN, finding genotype-specific differences in cell-cycle timing that exceed within-strain variation.

The paper characterizes a unique cluster of Shigella-like organisms in Bangladesh, identifying them as potentially a new serotype of S. boydii based on phenotypic, genotypic, and serological analyses.

This study identifies Roseburia hominis-derived 10-hydroxystearic acid as a metabolite that improves metabolic health by restoring hepatic fatty acid metabolism in mice.

The paper maps gene regulators of endothelial cell differentiation using CRISPR and single-cell RNA-seq, identifying Hippo mechanosignaling as critical for endothelial identity.

This paper shows that targeting cellular S-acylation with synthetic compounds can spatially disrupt KRAS signaling and stress responses in cancer cells.

This study shows that light exposure during rearing induces a developmental switch in zebrafish body color response to light, independent of pineal photoreceptors.

This study develops alginate-based delivery systems for coral probiotics, showing increased probiotic colonization in treated corals.

This study identifies prenatal adversity and neonatal brain connectivity as predictors of infant sensory over-responsivity, which links to later behavioral problems.

This study shows that activating the AhR in TRPV1+ nociceptors reduces visceral hypersensitivity in post-colitis mice, suggesting AhR as a therapeutic target for IBD-related abdominal pain.

This study shows that northern juvenile Chinook salmon have high thermal tolerance and plasticity, with warm acclimation improving heat tolerance and cardiac function.