Armaan Mohan

This study shows that activating the AhR in TRPV1+ nociceptors reduces visceral hypersensitivity in post-colitis mice, suggesting AhR as a therapeutic target for IBD-related abdominal pain.

The paper identifies ataxia-linked MFN2 variants that increase ferroptosis susceptibility by enhancing fatty acid import from lipid droplets to mitochondria, leading to lipid peroxidation and cell death.

The paper identifies a novel MFN2 variant, Q367H, linked to mtDNA-mediated inflammation in a patient with distal myopathy, revealing a pathomechanism connecting MFN2 dysfunction to inflammatory signaling.

The paper describes a protocol to measure mtDNA synthesis, turnover, and supercoiling using selective bromodeoxyuridine incorporation and Southwestern blotting.

The paper introduces a genetic fluorescent reporter, mt-HI-NESS, to visualize mitochondrial nucleoids in live cells without affecting mtDNA replication or expression.