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Cell-in-drop genotyping detects megabase-scale loss of heterozygosity as a quantitative marker for CRISPR-Cas9 on-target toxicity

Homoplastic evolution of proximal podomere patterning across Arthropoda

The paper examines proximal podomere patterning in sea spiders and arachnids, finding homoplastic evolution of gene expression patterns that challenges assumptions about leg segment homology.

The Almond Expression Atlas: A comprehensive multi-tissue transcriptomic resource for almond gene expression

The paper presents the Almond Expression Atlas, a comprehensive transcriptomic resource integrating RNA-seq data to identify tissue-specific genes and improve gene expression analysis in almond.

Optimal Conservation Prioritization for Waterfowl and Other Birds in Eastern Canada

The paper presents an optimized geospatial prioritization scheme for bird conservation in Eastern Canada using linear programming to maximize population coverage.

Phloem conductance from leaf to fruits in avocado during development

The paper quantifies phloem conduit geometry and carbohydrate concentrations in avocado plants during development, showing changes in phloem structure and transport efficiency.

Dissection of the contribution of bushy cell delays to sound localization in juvenile and adult Mongolian gerbils

This study examines how delays in bushy cell axons contribute to sound localization in Mongolian gerbils, finding developmental changes in delay patterns and their impact on interaural time difference processing.

Quantifying subcellular organization from localization to co-occurrence with InSpace

InSpace quantifies subcellular organization by preserving localization and molecular co-occurrence, revealing spatial programs in B and plasma cells across cancers.

Cumulus cells mediate the protective effect of the marine carotenoid fucoxanthin against postovulatory oocyte aging via NRF2 signaling

This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.

Convergent genome- and gene-level constraints shape repeated environmental adaptation in grasses

This study identifies convergent genomic and gene-level constraints in grasses adapting to extreme environments using phylogenomic data and large language models.

ToxINsight: An Integrated Web Platform for Sequence, Structure, and Ligand Binding Analysis of Snake Venom Toxins

ToxINsight provides a web platform for analyzing snake venom toxin sequences, structures, ligand interactions, and geographical distributions to aid in antivenom development.

The cell polarity landscape in Arabidopsis male and female gametophytes

The paper identifies polar domains in Arabidopsis male and female gametophytes using conserved proteins, revealing a universal polarity system and uncovering novel polar domains.

Age Associated Shifts Toward Anaerobic Taxa and Amino Acid Degradation Potential in the Canine Oral Microbiome

This study examines age-related changes in the canine oral microbiome, finding increased anaerobic taxa and amino acid degradation potential with age.

Cannabidiol Impairs Glucagon Trafficking and Secretion Through the Lysosomal System in Murine αTC1-6 cells

This study shows that CBD reduces glucagon secretion in mouse αTC1-6 cells by altering lysosomal trafficking and secretion pathways.

Cross-regulatory sRNA networks shape adaptive stress responses in Staphylococcus aureus: RsaC and RsaOI regulate galactose metabolism and cell wall homeostasis

This study identifies regulatory interactions between sRNAs and transcription factors in S. aureus, showing their roles in stress responses and virulence.

No Effect of Exercise Timing on Daily Glycaemia Despite Shifts in Acute Glucose Dynamics in Participants with Normal Glucose Tolerance: A Randomised Crossover Trial

This study shows that exercise timing does not affect overall daily glucose exposure but alters acute glucose dynamics and variability.

Structure of influenza D virus NS1 reveals a novel Zn-binding site and ssRNA-binding activity

This study determines the structure of influenza D virus NS1, identifies a novel Zn-binding site and RNA-binding activity in its CTD, and shows their importance for viral replication.

NAD Metabolism Drives CTCF-Cohesin Chromatin Regulation in EBV-Transformed B-Cells

This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.

Investigating the therapeutic potential of soluble TREM2 interactions with Transgelin-2 in Alzheimer's disease

This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.

Modeling ATN1 mutations in human iPSCs reveals early developmental roles of atrophin-1

This study generates an isogenic iPSC panel to investigate ATN1's role in human development and disease, revealing proliferation deficits and toxic gain-of-function effects in mutant ATN1 lines.

Nucleus accumbens acetylcholine dips track reward value and temporal costs to shape delay discounting

This study shows that nucleus accumbens acetylcholine dips track reward value and delay, influencing adaptive choice in mice during delay discounting tasks.