BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments
Rachel Daudin, Damien Maréchal, R Golgolab, Q Wang, Y Abe, T. Tsurugizawa, Nathalie Bourg, Maxime Sartori, Yann Loe-Mie, Joanna Lipecka, Ida Chiara Guerrera, A McKenzie, Brigitte Potier, P. Dutar, Julia Viard, , Michel Simonneau
This paper shows that BIN1 overexpression in mice leads to early structural and functional impairments in hippocampal pathways associated with Alzheimer's disease, independent of A-beta changes.
bioRxiv · Mar 9, 2021 · PreprintNeuroscience