Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation
A. Akef, K. McGraw, S. D. Cappell, D. R. Larson
This study shows that the U2AF1-S34F mutation disrupts ribosome biogenesis and translation, leading to increased mRNA translation and myeloid malignancy.
bioRxiv · Dec 13, 2019Cancer Biology