Author

D. R. Larson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Akef· 1 shared B. T. Donovan· 1 shared B. Wang· 1 shared C. H. Bohrer· 1 shared G. R. Garcia· 1 shared K. McGraw· 1 shared S. D. Cappell· 1 shared S. M. Mount· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 9 mutual co-author links

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1 shared paperCancer Biology

A. Akef

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Author profile →

3 papers

Recent·Most cited

REAL-TIME VISUALIZATION OF SPLICEOSOME ASSEMBLY REVEALS BASIC PRINCIPLES OF SPLICE SITE SELECTION

B. T. Donovan, B. Wang, G. R. Garcia, S. M. Mount, D. R. Larson

The paper applies a kinetic proofreading model to elucidate how transient U2AF binding leads to high fidelity splice site selection.

bioRxiv · Jul 12, 2024 · PreprintBiophysics

Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes

C. H. Bohrer, D. R. Larson

The paper uses single-cell imaging methods to show that physical distance, not genomic distance, drives co-bursting of gene transcription in human chromosomes.

bioRxiv · Jul 7, 2022Biophysics

Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

A. Akef, K. McGraw, S. D. Cappell, D. R. Larson

This study shows that the U2AF1-S34F mutation disrupts ribosome biogenesis and translation, leading to increased mRNA translation and myeloid malignancy.

bioRxiv · Dec 13, 2019Cancer Biology