Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations
Y. Lee, O. Haapanen, A. Altmeyer, W. Kühlbrandt, V. Sharma, V. Zickermann
The paper determines the structure of an Mrp antiporter using cryo-EM and simulates its mechanism, revealing a histidine-switch critical for ion translocation.
bioRxiv · Jan 24, 2022Biochemistry