V. Sharma

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

The TyphiNET data visualisation dashboard: Unlocking Salmonella Typhi genomics data to support public health

The paper introduces TyphiNET, a dashboard for exploring Typhi genomics data to support public health decisions on antimicrobial resistance and vaccine implementation.

Exploring Probiotic Potential: A Comparative Genomics and In Silico Assessment of Genes within the Genus Geobacillus

This study assesses the probiotic potential of Geobacillus by analyzing its genomic features, revealing safety traits and absence of virulence factors.

A framework for quality control in quantitative proteomics

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

The SET1 protein of Leishmania donovani moderates the parasite's response to a hostile oxidative environment

This study investigates the role of LdSET1 in Leishmania donovani, finding it moderates the parasite's response to oxidative stress in host macrophages, enabling infection persistence without host cell eradication.

Structural basis of respiratory complexes adaptation to cold temperatures

This study identifies a cold-induced conformation of respiratory complex CI:III2 using cryo-EM and simulations, revealing structural changes that enhance electron transfer efficiency in cold environments.

In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19

This study evaluates LCTG-002, a purified human milk sIgA product, showing it effectively reduces SARS-CoV-2 viral burden in mice.

Role of protonation states in stability of molecular dynamics simulations of high-resolution membrane protein structures

This study shows that using pre-determined protonation states in MD simulations improves structural accuracy for membrane proteins, highlighting the importance of protonation state calculations before simulations.

Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism

This study shows that sepiapterin reprograms M2-type tumor-associated macrophages in HER2+ breast tumors to M1-type by modulating arginine metabolism, enhancing immunotherapy response.

Long-term history dependence of growth rates of E. coli after nutrient shifts

This study shows that E. coli growth rates on carbon source combinations depend on prior growth conditions, persisting for 15 generations and involving the transcription factor Mlc.

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

Downregulation of ribosomal RNA (rRNA) genes in human head and neck squamous cell carcinoma (HNSCC) cells is linked to rDNA promoter hypermethylation

The paper shows that rRNA genes are downregulated and hypermethylated in HNSCC cell lines, suggesting a potential role in cancer prognosis and diagnosis.

Temporal Vascular Endothelial Growth Factor Sub-type gene Switching in SARS-CoV Pathogenesis. Interpretation through in vivo Murine C57BL Models

This study analyzes temporal gene expression patterns of VEGF-A and VEGF-B in a murine SARS-CoV model, revealing dynamic changes and potential interactions with SARS-CoV-2 Spike protein.

Exploring Capacitance and Non-Linear Electrokinetics in Nanopores Yields Insight into Single Molecule Recordings

The paper investigates nanopore electrokinetics, introducing a Warburg-like element to explain anomalous capacitance and filtering effects during molecular translocation.

Nanobody engineering for SARS-CoV-2 neutralization and detection

This study engineers nanobodies to neutralize SARS-CoV-2 variants and develop a detection assay, showing high potency against some variants but limitations against others.

Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma

This study identifies a novel monoclonal PD-L1 antibody H1A that enhances T-cell mediated tumor killing in renal cell carcinoma compared to existing PD-1/PD-L1 inhibitors.

Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex

The paper reveals the structural basis of mitochondrial membrane bending by the I-II-III2-IV2 supercomplex using cryo-EM and molecular dynamics simulations.

Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I

The paper uses molecular dynamics simulations to study how quinone derivatives move through the Q tunnel in complex I and how this movement couples with protein conformational changes.

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations

The paper determines the structure of an Mrp antiporter using cryo-EM and simulates its mechanism, revealing a histidine-switch critical for ion translocation.

Fast and cost-effective age estimation in Bengal tiger and Asiatic lion: applicability of cementum analysis method

This paper describes a fast and cost-effective age estimation method for Bengal tigers and Asiatic lions using cementum analysis of incisor teeth.

Horn trophy seized in illegal wildlife trade assigned to swamp buffalo using a combined morphometric and DNA based approach in wildlife forensics in India

The paper identifies a seized horn as belonging to a swamp buffalo using morphometric and DNA analysis, providing a protocol for species identification in wildlife forensics.

ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

The paper develops a monoclonal antibody cocktail (ZRC-3308) effective against multiple SARS-CoV-2 variants in Syrian hamsters.

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay

The paper shows that m6A modification recruits YTHDC2 to confer SOX resistance to IL-6 mRNA during KSHV lytic infection.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

RNA silencing by CRISPR in plants does not require Cas13

The paper shows that CRISPR-Cas13 can reduce RNA in plants without the Cas13 protein, using a mechanism similar to RNAi.

High-resolution structure and dynamics of mitochondrial complex I - insights into the proton pumping mechanism

The paper presents a high-resolution cryo-EM structure of mitochondrial complex I from Yarrowia lipolytica, revealing proton translocation pathways and conformational changes linked to proton pumping.

A novel approach to the detection of unusual mitochondrial protein change suggests low basal metabolism of ancestral anthropoids

This paper develops a method to detect rapid mitochondrial protein substitutions and finds reduced cellular metabolism in ancestral anthropoids.

Genome sequencing of the bacteriophage CL31 and interaction with the host strain Corynebacterium glutamicum ATCC 13032

This study sequenced the bacteriophage CL31 and analyzed its interaction with Corynebacterium glutamicum, revealing genomic features and infection dynamics.

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

This study identifies how primary tumor-associated macrophages prime disseminating tumor cells for invasion and dormancy, revealing a critical post-extravasation step in metastasis.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.