Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression
T. Montecchi, G. Nannini, D. De Tommaso, C. Cassioli, F. Coppola, M. N. Rigressi, F. Carraro, A. Naldini, A. Taddei, G. Marotta, A. Amedei, C. T. Baldari, C. Ulivieri
This study identifies Rai as a novel HIF-1-responsive gene upregulated in CRC TILs, which promotes T cell exhaustion by sustaining GSK-3 activation and PD-1 expression.
bioRxiv · Jun 23, 2023Cancer Biology