A. Taddei

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression

This study identifies Rai as a novel HIF-1-responsive gene upregulated in CRC TILs, which promotes T cell exhaustion by sustaining GSK-3 activation and PD-1 expression.

Physical observables to determine the nature of membrane-less cellular sub-compartments

The paper proposes a theoretical framework to distinguish between liquid-liquid phase separation and binding site models for membrane-less cellular sub-compartments using single molecule tracking experiments.

Single molecule microscopy reveals key physical features of repair foci in living cells

The paper uses single molecule microscopy to study the physical properties of repair foci in living cells, revealing differences in diffusion behavior between Rad52 and Rfa1 proteins.

The silencing factor Sir3 is a molecular bridge that sticks together distant loci

This study shows Sir3 bridges distant genomic loci, promoting long-range contacts and rDNA compaction in yeast, independent of its known partners.

Significant and conflicting correlation of IL-9 with Prevotella and Bacteroides in human colorectal cancer

The paper investigates the correlation between IL-9 and gut microbiota in colorectal cancer, finding conflicting associations with Prevotella and Bacteroides.