Human-derived alleles in SOST and RUNX2 3'UTRs cause differential regulation in a bone cell-line model
J. Moriano, N. Martinez-Gil, A. Andirko, S. Balcells, D. Grinberg, C. Boeckx
The paper evaluates the functional impact of 3'UTR variants in SOST and RUNX2 from human and Neanderthal/Denisovan lineages in a bone cell-line model, finding differential regulation linked to bone mineral density.
bioRxiv · Apr 21, 2021 · PreprintEvolutionary Biology