The paper identifies archaic admixture in eastern gorillas using whole genome sequences and ABC with neural networks, finding introgression from a ghost lineage into their common ancestor.

DOI 10.1101/2022.12.19.521012

whole-genome sequencingstatistical model

𝕏 PostBluesky

Evolutionary BiologyGenome Biology and EvolutionPeer-reviewedMay 26, 2021

HuConTest: Testing human contamination in great ape samples

M. Kuhlwilm, C. Fontsere, S. Han…·T. Marques-Bonet

HuConTest detects human contamination in short read sequencing data from great apes using blood and tissue samples, showing its utility in complex samples with low endogenous DNA.

DOI 10.1093/gbe/evab117

humannon-human primate

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintJan 22, 2021

Fine-grained temporal mapping of derived high-frequency variants supports the mosaic nature of the evolution of Homo sapiens

A. Andirko, J. Moriano, A. Vitriolo…·C. Boeckx

The paper temporally maps high-frequency variants in Homo sapiens to support a mosaic evolutionary model, finding bimodal distributions and time-specific gene enrichments.

DOI 10.1101/2021.01.22.427608

humanwhole-genome sequencing

𝕏 PostBluesky

Evolutionary BiologybioRxivDec 18, 2019

Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

R. Garcia-Perez, P. Esteller-Cucala, G. Mas…·T. Marques-Bonet

The paper profiles epigenomic features in primate LCLs to reveal evolutionary patterns of epigenetic activity in gene regulation.

DOI 10.1038/s41467-021-23397-1

humanchicken / avian

𝕏 PostBluesky

Evolutionary BiologybioRxivJan 20, 2019

A catalog of single nucleotide changes distinguishing modern humans from archaic hominins

M. Kuhlwilm, C. Boeckx

The paper identifies 571 genes with non-synonymous changes at high frequency in modern humans, suggesting they may contribute to uniquely human traits.

DOI 10.1038/s41598-019-44877-x

humanwhole-genome sequencing

𝕏 PostBluesky