Multivariate 'AND-gate' substrate probes as enhanced contrast agents for fluorescence-guided surgery
J. C. Widen, M. Tholen, J. J. Yim, A. antaris, K. M. Casey, S. Rogalla, A. Klaassen, J. Sorger, M. Bogyo
This paper introduces multivariate AND-gate optical imaging probes that improve specificity and sensitivity for cancer margin detection during surgery by requiring sequential processing by multiple tumor-specific enzymes.
bioRxiv · Jun 8, 2020 · PreprintBioengineering