S. Rogalla

SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model

This study evaluates a 177Lu-labeled integrin αvβ6-targeting knottin peptide for imaging and therapy of pancreatic cancer using xenograft models, showing high tumor accumulation and moderate kidney uptake.

GPR15 in colon cancer development and anti-tumor immune responses.

This study investigates the role of GPR15 in colon cancer, showing its deficiency promotes tumor growth by altering immune responses, and identifies GPR15L as a potential therapeutic target.

Multivariate 'AND-gate' substrate probes as enhanced contrast agents for fluorescence-guided surgery

This paper introduces multivariate AND-gate optical imaging probes that improve specificity and sensitivity for cancer margin detection during surgery by requiring sequential processing by multiple tumor-specific enzymes.