Author

K. M. Casey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Assay:imaging· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. von Eyben· 2 shared A. antaris· 1 shared A. C. Koong· 1 shared A. J. Giaccia· 1 shared A. Kim· 1 shared A. Klaassen· 1 shared A. Kuo· 1 shared A. S. Yu· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

R. von Eyben

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Author profile →

5 papers

Recent·Most cited

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

K. Pedram, D. J. Shon, G. S. Tender, N. R. Mantuano, J. J. Northey, K. J. Metcalf, S. P. Wisnovsky, N. M. Riley, G. C. Forcina, S. A. Malaker, A. Kuo, B. M. George, C. L. Miller, K. M. Casey, J. G. Vilches-Moure, , C. R. Bertozzi

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

bioRxiv · May 20, 2022Biochemistry

Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy

M. M. Olcina, S. Melemenidis, D. K. Nambiar, R. K. Kim, K. M. Casey, R. von Eyben, T. M. Woodruff, E. G. Graves, Q.-T. Le, M. Stucki, A. J. Giaccia

This study shows that targeting C5aR1 with PMX205 improves tumor radiation response and reduces normal tissue toxicity in mice.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology

Multivariate 'AND-gate' substrate probes as enhanced contrast agents for fluorescence-guided surgery

J. C. Widen, M. Tholen, J. J. Yim, A. antaris, K. M. Casey, S. Rogalla, A. Klaassen, J. Sorger, M. Bogyo

This paper introduces multivariate AND-gate optical imaging probes that improve specificity and sensitivity for cancer margin detection during surgery by requiring sequential processing by multiple tumor-specific enzymes.

bioRxiv · Jun 8, 2020 · PreprintBioengineering

FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

K. Levy, S. Natarajan, J. Wang, S. Chow, J. T. Eggold, P. Loo, R. Manjappa, F. M. Lartey, E. Schüler, L. Skinner, M. Rafat, R. Ko, A. Kim, D. Al Rawi, R. von Eyben, , E. B. Rankin

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

bioRxiv · Dec 12, 2019 · PreprintCancer Biology

Histologic safety of transcranial focused ultrasound neuromodulation and magnetic resonance acoustic radiation force imaging in rhesus macaques and sheep

P. Gaur, K. M. Casey, J. Kubanek, N. Li, M. Mohammadjavadi, Y. Saenz, G. H. Glover, D. M. Bouley, K. Butts Pauly

This study evaluates the histologic safety of transcranial focused ultrasound neuromodulation and MR-ARFI in rhesus macaques and sheep, finding no FUS-related tissue damage.

bioRxiv · Nov 1, 2019Bioengineering