TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates
R. K. Singh, A. S. Haka, A. Asmal, V. C. Barbosa-Lorenzi, I. Grosheva, H. F. Chin, Y. Xiong, T. Hla, F. R. Maxfield
This study shows TLR4 signaling promotes extracellular catabolism of LDL aggregates and lipid accumulation in macrophages through lysosomal synapse formation.
bioRxiv · Apr 15, 2019 · PreprintCell Biology