Author

T. Hla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Cartier· 3 shared A. Kuo· 3 shared A. Inoue· 2 shared S. Galvani· 2 shared S. Swendeman· 2 shared T. Seno· 2 shared A. Asmal· 1 shared A. Culbertson· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

A. Cartier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal vasculopathy

C. Niaudet, B. Jung, A. Kuo, S. Swendeman, E. Bull, T. Seno, R. Crocker, Z. Fu, L. E. H. Smith, T. Hla

The paper shows that activating endothelial S1PR1 with HDL-bound S1P or a Gi-biased agonist suppresses neovascular tufts in retinopathy models.

bioRxiv · Jun 14, 2022 · PreprintPathology

Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

S. Swendeman, D. Lin, S. Guo, A. Culbertson, A. Kuo, M. Levesque, A. Cartier, T. Seno, A. Schmaier, S. Galvani, A. Inoue, S. Parikh, G. A. FitzGerald, M. Liao, R. Flaumenhaft, T. Hla

This paper constructs engineered HDL-like particles that chaperone bioactive lipids to reduce inflammation and endothelial dysfunction.

bioRxiv · Feb 14, 2022 · PreprintBiochemistry

TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates

R. K. Singh, A. S. Haka, A. Asmal, V. C. Barbosa-Lorenzi, I. Grosheva, H. F. Chin, Y. Xiong, T. Hla, F. R. Maxfield

This study shows TLR4 signaling promotes extracellular catabolism of LDL aggregates and lipid accumulation in macrophages through lysosomal synapse formation.

bioRxiv · Apr 15, 2019 · PreprintCell Biology

Endothelial sphingosine 1-phosphate receptors promote vascular normalization to influence tumor growth and metastasis

A. Cartier, T. Leigh, C. H. Liu, T. Hla

This study shows that S1PR1 in tumor vessels promotes vascular normalization, reducing tumor growth and metastasis, and enhances the effectiveness of chemotherapy.

bioRxiv · Apr 12, 2019Cancer Biology

Heterotypic inter-GPCR β-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes

Y. Hisano, M. Kono, E. Engelbrecht, K. Kawakami, K. Yanagida, A. Cartier, S. Galvani, A. Kuo, Y. Ono, S. Ishida, J. Aoki, R. L. Proia, A. Inoue, T. Hla

The paper identifies LPAR1-induced S1PR1/β-arrestin coupling as a mechanism regulating lymphatic endothelial junctional architecture in murine lymph nodes.

bioRxiv · Oct 4, 2018Cell Biology