Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas
A. M. Fordham, L. M. Brown, C. Mayoh, A. Salib, Z. A. Barger, M. Wong, T. C. C. L. K. Sian, J. Xie, K. Gunther, P. Trebilcock, R. L. Terry, P. Barahona, P. Ajuyah, A. Sherstyuk, A. Avila, , E. D. Fleuren
The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.
bioRxiv · Jul 19, 2023 · PreprintCancer Biology