M. Wong

Genomic surveillance of multidrug-resistant organisms based on long-read sequencing

This study demonstrates that long-read sequencing is as accurate and more cost-effective than short-read sequencing for molecular characterization of multidrug-resistant organisms.

Highly Multiplexed Fluorescence Microscopy with Spectrally Tunable Semiconducting Polymer Dots

This paper introduces a method for highly multiplexed fluorescence microscopy using tunable semiconducting polymer dots, enabling imaging of up to 21 targets in a single round.

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution

This study tracks SARS-CoV-2 evolution through 33-100 serial passages in vitro, identifying convergent mutations that may confer fitness or transmissibility advantages.

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

Does Vaping Increase the Likelihood of SARS-CoV-2 Infection? Paradoxically Yes and No

This study investigates whether vaping increases SARS-CoV-2 infection in human bronchial epithelial cells, finding that certain e-liquid ingredients enhance infection while others reduce it.

New Insights into How JUUL Electronic Cigarette Aerosols and Aerosol Constituents Affect SARS-CoV-2 Infection of Human Bronchial Epithelial Cells

This study shows that JUUL aerosols and their constituents increase SARS-CoV-2 infection in human bronchial epithelial cells by boosting ACE2 and TMPRSS2 levels.

Metabolic shift toward ketosis in asocial cavefish increases social-like affinity.

This study shows that a ketogenic diet increases social affinity in asocial cavefish, suggesting a link between metabolic shifts and social behavior.

Mechanisms governing protective pregnancy-induced adaptions of the pelvic floor muscles in the rat pre-clinical model

This study investigates how mechanical load during pregnancy affects pelvic floor muscle adaptations in rats, finding that load alone can induce structural changes that partially protect against birth injury.

Environmental and genetic disease modifiers of haploinsufficiency of A20

The paper identifies genetic and environmental modifiers that exacerbate autoinflammatory disease caused by A20 haploinsufficiency in humans.

Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases

The paper shows that cells use different pools of GDP-fucose for glycosylation, depending on the origin of the monosaccharide, and that this selection is tightly regulated.

The role of muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury

This study shows that muscle stem cells and fibro-adipogenic progenitors are essential for pelvic floor muscle recovery after birth injury, as their loss impairs regeneration in a rat model.

Mega- and meta-analyses of fecal metagenomic studies assessing response to immune checkpoint inhibitors

The paper performs meta- and mega-analyses of fecal metagenomic data from four cohorts to identify bacterial species associated with response to immune checkpoint inhibitors.

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

The paper shows that bone marrow adipocyte whitening during obesity drives the increase of invasive Ly6Chigh monocytes, preceding adipose tissue macrophage expansion.

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

This paper introduces LINX, a tool for analyzing structural variation and copy number alterations in cancer genomes, revealing novel insights into oncogenic fusions and inactivation events.

SARS-CoV-2 infects carotid arteries: implications for vascular disease and organ injury in COVID-19

The paper investigates SARS-CoV-2 infection in carotid arteries of COVID-19 patients using genomic, virologic, histochemical, and transcriptomic analyses, showing productive infection and vascular modulation.

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

A Holistic Analysis of the Intestinal Stem Cell Niche Network

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

PGRMC1 phosphorylation and cell plasticity 2: genomic integrity and CpG methylation

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

Gradual decrease in the inter-population diversity of HIV-1 Env among group M lineages worldwide

The paper analyzes the evolution of HIV-1 Env diversity across clades and regions, finding that inter-population diversity decreases while intra-population diversity increases due to conserved selective pressures.

Isolation of muscle stem cells from rat skeletal muscles

This paper develops and validates a protocol for isolating muscle stem cells from rat skeletal muscles using CD106 as a marker.

Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial Phenotype

This study shows that combining mechanical strain and kinase inhibitors enhances mesenchymal stem cells to express pericyte and endothelial markers, improving their angiogenic capabilities.

High Throughput Mechanobiological Screens Enable Mechanical Priming of Pluripotency in Mouse Fibroblasts

The paper identifies small molecules that synergize with mechanical loading to prime pluripotency in mouse fibroblasts using high throughput mechanobiological screens.

The double tubular contractile structure of the type VI secretion system displays striking flexibility and elasticity

This study reveals the flexible and elastic nature of the T6SS double tubular structure, showing it can deform into various shapes while maintaining function, and proposes a new contraction model.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

A human impact metric for coastal ecosystems with application to seagrass beds in Atlantic Canada

The paper develops a human impact metric for coastal ecosystems and applies it to seagrass beds in Atlantic Canada, revealing regional variations in anthropogenic stressors.