A. Zhao

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Androgens modulate the immune profile in a mouse model of polycystic ovary syndrome

This study shows that androgen exposure in a mouse PCOS model alters immune cell populations in reproductive and metabolic tissues, with effects mediated through androgen receptors.

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner.

This study identifies MCEMP1 as highly expressed in monocytes and macrophages in IPF, regulated by TGFβ and involved in chemotaxis, adhesion, and migration through RHO GTPase modulation.

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

Mapping the T cell repertoire to a complex gut bacterial community

The paper maps T cell responses to a complex gut bacterial community and identifies a conserved antigen recognized by multiple TCRs.

Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

This study identifies MroQ as the second protease in the S. aureus agr quorum sensing pathway, showing its role in AIP biosynthesis and revealing molecular features guiding its cleavage activity.

Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes

This study shows that hyperglycemia represses HIF-1, leading to increased mitochondrial ROS production and renal injury in diabetes, which can be mitigated by restoring HIF-1 function.

In vivo augmentation of a complex gut bacterial community

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

Identification of CD4+ Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial Fibrosis

The paper identifies a CD4+ subpopulation of resident cardiac fibroblasts linked to myocardial fibrosis, showing their transdifferentiation from mesenchymal to lymphoid-like cells via the IL-1β-IL-1R-NFκB pathway.

A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease

This study identifies a metabolic pathway involving pyruvate decarboxylases that contributes to plant resistance against bacterial wilt disease, and shows how a bacterial effector inhibits this pathway to promote disease.

Multi-modal single cell analysis reveals brain immune landscape plasticity during aging and gut microbiota dysbiosis

This study uses CITE-seq to analyze brain immune cell plasticity in aged mice with and without gut dysbiosis, revealing transcriptional shifts in monocytes and ILCs linked to neuroinflammation.

Tomato root transformation followed by inoculation with Ralstonia solanacearum for straightforward genetic analysis of bacterial wilt disease

This paper develops a method for genetic analysis of Ralstonia solanacearum infection in tomato by transforming roots and inoculating with the pathogen, demonstrating resistance via RNAi silencing of SlCESA6.

Flavor compounds in fermented Chinese alcoholic beverage alter gut microbiota and attenuate ethanol-induced liver

This study shows that Chinese Baijiu reduces liver injury in mice by altering gut microbiota and metabolome compared to pure ethanol.