Author

A. B. Janssen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Bonten· 3 shared R. J. L. Willems· 3 shared W. van Schaik· 3 shared D. J. Doorduijn· 2 shared J. A. Bengoechea· 2 shared J.-W. Veening· 2 shared A. M. Bravo· 1 shared A. Stream· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

M. Bonten

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Author profile →

6 papers

Recent·Most cited

An efficient in vivo-inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies

E. Bjanes, A. Stream, A. B. Janssen, P. S. Gibson, A. M. Bravo, S. Dahesh, J. L. Baker, A. Varble, V. Nizet, J.-W. Veening

This paper develops a doxycycline-inducible CRISPRi system for GAS to enable efficient gene repression and presents a genome browser for GAS genetic features.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors

A. B. Janssen, V. de Bakker, R. Aprianto, V. Trebosc, C. Kemmer, M. Pieren, J.-W. Veening

This study shows that OmpR in Klebsiella pneumoniae regulates virulence and lung infection by controlling key virulence factors and eliciting a strong host transcriptional response.

bioRxiv · Jul 31, 2023 · PreprintMicrobiology

Colistin resistance mutations in phoQ sensitize Klebsiella pneumoniae to IgM-mediated complement killing

S. P. A. van der Lans, M. Janet-Maitre, F. M. Masson, K. A. Walker, D. J. Doorduijn, A. B. Janssen, W. van Schaik, I. Attree, S. H. M. Rooijakkers, B. W. Bardoel

This study shows that colistin resistance mutations in K. pneumoniae increase sensitivity to IgM-mediated complement killing via PhoQ activation.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology

Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract.

A. B. Janssen, D. van Hout, M. Bonten, R. J. L. Willems, W. van Schaik

This study identifies mechanisms of acquired colistin resistance in Enterobacteriaceae from ICU patients on SDD, revealing novel variants and highlighting resistance emergence during prophylactic use.

Journal of Antimicrobial Chemotherapy · Jul 26, 2020Peer-reviewedMicrobiology

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics.

A. B. Janssen, D. J. Doorduijn, G. Mills, M. R. C. Rogers, M. Bonten, S. Rooijakkers, R. J. L. Willems, J. A. Bengoechea, W. van Schaik

This study shows that Klebsiella pneumoniae complex strains can develop colistin resistance through multiple evolutionary paths, with variable effects on fitness and virulence.

bioRxiv · May 24, 2020Microbiology

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two component system in Escherichia coli bloodstream isolates

A. B. Janssen, T. L. Bartholomew, N. P. Marciszewska, M. Bonten, R. J. L. Willems, J. A. Bengoechea, W. Schaik

This study identifies mutations in the BasRS two-component system as a novel mechanism of colistin resistance in E. coli bloodstream isolates, independent of plasmid-mediated resistance.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology