Author

R. Aprianto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Approach:statistical model· 4 Approach:deep learning· 3 Approach:experimental assay· 3

Frequent Co-Authors

J.-W. Veening· 6 shared J. Slager· 3 shared A. B. Janssen· 1 shared A. Domenech· 1 shared C. Kemmer· 1 shared C. M. J. E. Vandenbroucke-Grauls· 1 shared C. Trappetti· 1 shared D. van de Beek· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersMicrobiology

J.-W. Veening

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors

A. B. Janssen, V. de Bakker, R. Aprianto, V. Trebosc, C. Kemmer, M. Pieren, J.-W. Veening

This study shows that OmpR in Klebsiella pneumoniae regulates virulence and lung infection by controlling key virulence factors and eliciting a strong host transcriptional response.

bioRxiv · Jul 31, 2023 · PreprintMicrobiology

Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole animal dual RNA-seq

K. K. Jim, R. Aprianto, A. Domenech, J. Kurushima, D. van de Beek, C. M. J. E. Vandenbroucke-Grauls, W. Bitter, J.-W. Veening

bioRxiv · Feb 10, 2022Microbiology

In Vivo Dual RNA-Seq Analysis Reveals the Basis for Differential Tissue Tropism of Clinical Isolates of Streptococcus pneumoniae

V. Minhas, R. Aprianto, L. J. McAllister, H. Wang, S. C. David, K. T. McLean, I. Comerford, S. R. McColl, J. C. Paton, J.-W. Veening, C. Trappetti

This study uses dual RNA-seq to show how a single SNP in Streptococcus pneumoniae affects bacterial and host gene expression, leading to differential tissue tropism and disease outcomes.

bioRxiv · Dec 3, 2019Microbiology

Refining the pneumococcal competence regulon by RNA-sequencing

J. Slager, R. Aprianto, J.-W. Veening

The paper uses RNA-seq to refine the pneumococcal competence regulon, identifying 4% of genes directly controlled by ComE/ComX and up to 17% affected overall.

bioRxiv · Dec 14, 2018Microbiology

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

R. Aprianto, J. Slager, S. Holsappel, J.-W. Veening

This study profiles the pneumococcal transcriptome under 22 infection-relevant conditions, revealing dynamic gene expression and identifying a new competence regulon member.

bioRxiv · Jul 11, 2018Microbiology

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

J. Slager, R. Aprianto, J.-W. Veening

This study annotates the genome of Streptococcus pneumoniae D39 using long-read sequencing and transcriptomics, identifying new genes, sRNAs, and operon structures.

bioRxiv · Jun 11, 2018Microbiology